Clinical case of long-term treatment of patient with uterine high-grade leiomyosarcoma

Abstract

Uterine leiomyosarcoma refers to malignant tumors with an aggressive course, poor prognosis, and unsatisfactory long-term treatment results. The five-year overall survival rate ranges from 52–85% for the first stage of the disease to 10–29% for the fourth stage. The treatment method that determines the prognosis of both localized and disseminated leiomyosarcomas is currently radical surgery. In the case of unresectable leiomyosarcomas, drug therapy is performed. The problem of choosing the optimal treatment method for each patient with leiomyosarcoma is still relevant. We present a case of long-term treatment of a patient with high-grade uterine leiomyosarcoma from our own clinical practice. During treatment, the patient underwent 4 surgical interventions and 9 lines of drug therapy. At the moment, the patient is in the process of 10 lines of treatment. Duration of life from the moment of diagnosis is 108 plus months, and from the moment of dissemination of the disease is 97 plus months. This clinical case shows that timely performance of radical surgical interventions and rational choice of drug therapy regimens can significantly increase the average survival rate.