Abstract
Klinefelter's syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia-M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corresponding to Klinefelter's syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.
Highlights
KEK- 34-year-old man diagnosed with acute myelomonoblastic leukemia (AML- M4), determined for the first time during his stay in the clinic in July 2006, when he entered with com
Plaints of weakness, fatigue at normal physical analysis of bone marrow during diagnosticaly Abstract n Klinefelter’s syndrome is characterized by o abnormal karyotype 47, XXY and a phenotype e associated with hypogonadism and gynecomastia
Often the disease can be diagnosed s accidentally, when carrying out cytogenetic u analysis in cases of a malignant blood disease. l We present the clinical case of a patient diagia nosed with acute myelomonoblastic leukemia
Summary
KEK- 34-year-old man diagnosed with acute myelomonoblastic leukemia (AML- M4), determined for the first time during his stay in the clinic in July 2006, when he entered with com-. Bulgaria; 2Flow cytometric laboratory, University Hospital, Pleven, Bulgaria; 3Laboratory of cytogenetic and molecular biology, National Hospital of Hematological Disease, Sofia, Bulgaria Plaints of weakness, fatigue at normal physical analysis of bone marrow during diagnosticaly Abstract n Klinefelter’s syndrome is characterized by o abnormal karyotype 47, XXY and a phenotype e associated with hypogonadism and gynecomastia.
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