Abstract
Recently, akanthamoeba keratitis (AK) is seen more and more often in ophthalmological practice. However, today there are no standard guidelines concerning diagnosis and treatment of patients with AK. In the article, the experience in care for such patients is presented.
 Purpose: to estimate the efficiency of diagnosis and treatment of patients with AK.
 Materials and methods. Case histories of patients, who received treatment for akanthamoeba keratitis in the Eye Microsurgery Department No. 4, City Ophthalmologic Center of the City Hospital No. 2, from 2011 to 2016, were analyzed. Under observation, there were 25 patients (26 eyes) with akanthamoeba keratitis aged from 18 to 77 years; there were 15 men and 10 women. Patients were observed during 1 year. Full ophthalmologic examination was conducted in all patients. Additional diagnostic methods included microbiological investigation of corneal scrapes and washings, culturing them on innutritious agar (with E. сoli covering), confocal corneal microscopy (HRT 3 with cornea module, Heidelberg Retina Tomograph Rostock Cornea Module). A superficial punctate keratits (AK stage 2) was found in one patient. All other patients were divided into two groups. Stromal ring-shaped keratitis was diagnosed in patients of the first group (7 patients, AK stage 3). The 2nd group consisted of 17 patients with corneal ulcer (AK stage 4). All patients received medicamentous treatment. However patients of the 2nd group required different kinds of surgical treatment.
 Results. In AK diagnosis, corneal confocal microscopy is the most informative method. In patients with AK stages 2 and 3, there was an improvement in visual functions as a result of medicamentous therapy. As a result of treatment at the discharge from the hospital, the best corrected visual acuity was 0.5-1.0 for most patients. In the 2nd group patients, who were subjects to different types of surgical treatment visual functions stabilized. However non-compliance with recommendations led to disease recurrences with worse outcomes in four cases.
 Conclusion. It is possible to stop the inflammatory process preserving at the same time high visual functions only when patients are addressed in time, and when appropriate AK therapy is prescribed and patients are compliant with it for a long time.
Highlights
В последнее время акантамёбный кератит (АК) всё чаще встречается в практике врача-офтальмолога
Stromal ring-shaped keratitis was diagnosed in patients of the first group (7 patients, akanthamoeba keratitis (AK) stage 3)
The 2nd group consisted of 17 patients with corneal ulcer (AK stage 4)
Summary
Для цитирования: Скрябина Е.В., Астахов Ю.С., Коненкова Я.С., и др. Тактика ведения пациентов с акантамёбным кератитом // Офтальмологические ведомости. Однако на сегодняшний день нет общепринятых рекомендаций, касающихся диагностики и лечения пациентов с АК. Цель — оценить эффективность диагностики и лечения пациентов с акантамёбным кератитом. У пациентов 1-й группы (7 чел.) диагностирован стромальный кольцевидный кератит (3-я стадия АК). Во 2-ю группу вошли 17 пациентов с язвой роговицы (4-я стадия АК). Все пациенты получали консервативную терапию, однако пациентам 2-й группы потребовалось проведение различных видов хирургического лечения. У пациентов 2-й группы (4-я стадия АК), получивших различные виды хирургической помощи, стабилизировались зрительные функции. Купировать воспалительный процесс, сохранив при этом высокие зрительные функции, возможно лишь при своевременном обращении пациентов, назначении и соблюдении терапии АК в течение длительного времени. Ключевые слова: акантамёбный кератит; контактные линзы; конфокальная микроскопия; катионные антисептики; аутоконъюнктивотенонопластика роговицы
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