Abstract
National data from Scotland (all births from 2000 to 2011) were used to estimate the burden associated with respiratory syncytial virus hospitalisation (RSVH) during the first 2 years of life. RSVHs were identified using the International Classification of Diseases 10th Revision codes. Of 623,770 children, 13,362 (2.1%) had ≥ 1 RSVH by 2 years, with the overall rate being 27.2/1000 (16,946 total RSVHs). Median age at first RSVH was 137 days (interquartile range [IQR] 62–264), with 84.3% of admissions occurring by 1 year. Median length of stay was 2 (IQR 1–4) days and intensive care unit (ICU) admission was required by 4.3% (727) for a median 5 (IQR 2–8) days. RSVHs accounted for 6.9% (5089/73,525) of ICU bed days and 6.2% (64,395/1,033,121) of overall bed days (5370/year). RSVHs represented 8.5% (14,243/168,205) of all admissions between October and March and 14.2% (8470/59,535) between December and January. RSVH incidence ranged from 1.7 to 2.5%/year over the study period. Preterms (RSVH incidence 5.2%), and those with congenital heart disease (10.5%), congenital lung disease (11.2%), Down syndrome (14.8%), cerebral palsy (15.5%), cystic fibrosis (12.6%), and neuromuscular disorders (17.0%) were at increased risk of RSVH.Conclusions: RSV causes a substantial burden on Scottish paediatric services during the winter months.What is known:• Respiratory syncytial virus (RSV) is a leading cause of childhood hospitalisation.What is new:• This 12-year study is the first to estimate the burden of RSV hospitalisation (RSVH) in Scotland and included all live births from 2000 to 2011 and followed > 600,000 children until 2 years old.• The overall RSVH rate was 27.2/1000 children, with 2.1% being hospitalised ≥ 1 times.• RSVHs accounted for 6.2% of all inpatient bed days, which rose to 14.2% during the peak months of the RSV season (December–January), equating to over 1400 hospitalisations and nearly 5500 bed days each year.
Highlights
Materials and methods Study populationData on all live births were extracted from the Information Services Division (ISD) Scottish Maternity and Birth Record dataset (SMR02) for the period 2000–2011 and each child was followed for 2 years
This 12-year study is the first to estimate the burden of Respiratory syncytial virus (RSV) hospitalisation (RSVH) in Scotland and included all live births from 2000-2011 and followed > 600,000 children until 2 years old
The overall RSVH rate was 27.2/1,000 children, with 2.1% being hospitalised ≥ 1 times; RSVHs accounted for 6.2% of all inpatient bed days, which rose to 14.2% during the peak months of the RSV season (December-January), equating to over 1,400 hospitalisations and nearly 5,500 bed days each year
Summary
Data on all live births were extracted from the ISD Scottish Maternity and Birth Record dataset (SMR02) for the period 2000–2011 and each child was followed for 2 years. Those who died during the study period for any reason other than RSV-related infection, those whose records were unable to be linked between datasets (SMR02, Scottish Birth Record [SBR], General/Acute Inpatient and Day Case Record [SMR01], and Outpatient Attendance Record [SMR00]), or those who moved away from Scotland were excluded. Quantifying the burden of RSV LRTI at a national level can be difficult, due to the limited availability of suitable data sources and a lack of routine testing and confirmatory diagnoses of RSV. No studies reporting such data from Scotland have been published
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