Clinical Bioinformatics in Human Proteomics Research

Abstract

AbstractProteome analysis has rapidly developed in the post-genome era and is now widely accepted as a complementary technology to genetic profiling. The improvement in the technology of both two-dimensional electrophoresis (2-DE) analysis as well as quantitative iTRAQ has made proteomics a valuable and powerful tool to study human diseases. Clinical bioinformatics, emerging science combining clinical informatics, bioinformatics, medical informatics, information technology, mathematics, and omics science together, can be considered to be one of critical elements addressing clinical relevant challenges in early diagnosis, efficient therapies, and predictive prognosis of patients with disease. A combination of proteome analysis with clinical bioinformatics has been developed as a promising experimental approach for the identification of diagnostic and prognostic markers and so on, suggesting that proteome-based analysis is a promising tool for the identification of prognostic and diagnostic markers as well as for novel therapeutic targets which could be used for the treatment of diseases. The integration of proteome-based approaches with data from genomic or genetic profiling will lead to a better understanding of different diseases, which will then contribute to the direct translation of the research findings into clinical practice.KeywordsClinical bioinformaticsProteomicsBiomarkerNetwork