Abstract
Researchers at Autonomous University of Madrid, and other centers in Spain studied the clinical, biochemical, and genetic spectrum of pyridoxine-dependent epilepsy (PDE) in 12 patients with the clinically proven diagnosis.
Highlights
pyridoxine-dependent epilepsy (PDE) should be considered in any infant with intractable seizures, including patients with MRI abnormalities such as corpus callosum dysgenesis or Dandy Walker syndrome
Researchers at King’s College, London; Kyushu University, Japan; and Barcelona, Spain conducted a meta-analysis of functional magnetic resonance imaging in ADHD during inhibition and attention tasks, with reference to age and effects of long-term use of stimulant medication
Patients with ADHD have cognitive dysfunctions in right fronto-basal ganglia-thalamic networks, and long-term stimulant medication is associated with normalization of right caudate deficits during attention
Summary
CLINICAL, BIOCHEMICAL, AND MOLECULAR STUDIES AND TREATMENT OF PYRIDOXINE-DEPENDENT EPILEPSY Researchers at Autonomous University of Madrid, and other centers in Spain studied the clinical, biochemical, and genetic spectrum of pyridoxine-dependent epilepsy (PDE) in 12 patients with the clinically proven diagnosis. The effective dose of pyridoxine to suppress seizures ranged from 10 to 30 mg/kg/day.
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