Clinical behavior of retroperitoneal sarcomas that express HIF-1α, PHD2 and/or VEGF

Abstract

10589 Background: Tumor hypoxia is correlated to poorer prognosis in certain cancers but few studies have assessed hypoxia in retroperitoneal sarcomas (RS). Here, we correlate clinical behavior of RS to tumor expression of hypoxia related proteins (HRPs): hypoxia inducible factor 1α (HIF-1α), prolyl hydroxylase domain protein 2 (PHD2) and vascular endothelial growth factor (VEGF). Methods: RS were resected in 56 patients (April 1996 to July 2005) with 43 patients having complete clinical and pathology data. A retrospective review was done looking at age, gender, local (pain/distension) and systemic (fever/weight loss) symptoms, tumor pathology and operative details. Immunohistochemistry was performed on sections from all 43 RS staining for HIF-1α, PHD2 and VEGF. Sections were scored as positive if ≥10% of cells stained positively. Staining patterns were correlated to clinical variables. Statistical analysis was done using ANOVA and 2 tailed chi-square tests. Results: Mean age was 64 years and 49% of patie...