Abstract
Objective.
 The aim of this study was to determine the usefulness of ozone therapy in the treatment of Infantile Cerebral Palsy (ICP). 
 
 Patients and methods.
 A non-controlled clinical assay was made in the Ozone Research Center (CIO), Havana, Cuba from January 2013 to January 2014. The sample was constituted by patients remitted to pediatrics consultation of CIO, to whom inclusion and exclusion criteria were applied. The study group involved 45 patients, from 1 month of birth to 8 years, with cerebral palsy of hypoxic-ischemic cause. The evaluation criteria were: evolution of the motor disorder according to the Gross Motor Function Classification System (GMFCS) scale, modification of muscle tone (Ashworth modified scale) and response to treatment (O’Brien modified scale). The way of administration was rectal insufflation; concentrations between 15, 20, 25 and 30 mg/L were used, volumes varied according to age, making calculation of the dose of ozone according to kilograms of weight. Cycles of 20 sessions, every 3 months were indicated, until completing 4 in 16 months. Patients were clinically evaluated, according to the scales used, before and after each cycle. 
 
 Results and Discussion.
 The best answer to treatment was obtained in the group aged ? 4 years. The variables analyzed showed a significant improvement when the ozone treatment concluded. With respect to the evolution of the motor disorder, in 65 % of cases it improved. In the group of children below 4 years, the response was better in relation to the muscle tone. Response to treatment, according to the relatives’ criteria, was of 70 % of the children with marked improvement in the tone and muscle function. 
 
 Conclusions. 
 The greatest percentage of patients improved in the evolution of the motor disorder; when the Manual Ability Classification System (MACS) scale was applied, more than half the patients showed an improvement. A high percentage of children get a satisfactory result regarding muscle tone and motor function. No side effects were present in any of the cases during the study.
Highlights
IntroductionInfantile Cerebral Palsy (ICP) is a descriptive term historically used to group, with therapeutic, epidemiologic and administrative objectives, diverse motor and postural disorders causing limitation in the activity, attributed to nonprogressive disorders that occurred in the brain developing during fetal stage or early infantile stage [1, 2]
The greatest percentage of patients improved in the evolution of the motor disorder; when the Manual Ability Classification System (MACS) scale was applied, more than half the patients showed an improvement
Infantile Cerebral Palsy (ICP) is a descriptive term historically used to group, with therapeutic, epidemiologic and administrative objectives, diverse motor and postural disorders causing limitation in the activity, attributed to nonprogressive disorders that occurred in the brain developing during fetal stage or early infantile stage [1, 2]
Summary
Infantile Cerebral Palsy (ICP) is a descriptive term historically used to group, with therapeutic, epidemiologic and administrative objectives, diverse motor and postural disorders causing limitation in the activity, attributed to nonprogressive disorders that occurred in the brain developing during fetal stage or early infantile stage [1, 2]. Its prevalence is between 1.5 and 3 per 1,000 born alive. It is generally classified as congenital or acquired, according to the time when the brain damage occurred [3,4,5,6,7]. Motor syndromes are evident by alterations of posture, of voluntary movements and reflexes, which leads to development of a significant physical disability. These patients present with other alterations of neurodevelopment (convulsions, psychomotor and language slowness, disorders in learning, paying attention and conduct) in different degrees. Clinical manifestations vary according to age of conception, etiology and localization of lesions or anomalies [8)]
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