Clinical authorization of amyloid PET in France: Towards a more precise diagnosis of Alzheimer's disease

Abstract

The recent clinical authorization of amyloid PET in France represents a crucial step for the nuclear medicine community involved in the diagnosis of Alzheimer's disease (AD). At the era of ATN (Amyloid, Tau, Neurodegeneration) biomarkers, amyloid PET fills a need in patients with an atypical or mixed clinical presentation, in particular young patients (<65 years old), when the lumbar puncture is contraindicated or not feasible for technical reasons. Importantly, a negative amyloid PET scan discards the diagnosis of AD. Furthermore, early phase imaging of amyloid PET allows to estimate the perfusion neuronal state, increasing the diagnostic value of such PET radiotracer. Its role could be further developed in routine care for the selection and monitoring of promising disease modifiers therapies.