Clinical Assessment of Antimicrobial Effects of Brazilian Green Propolis on Chronic Wounds

Abstract

Pharmacognosy Research,2022,14,3,251-255.DOI:10.5530/pres.14.3.36Published:July 2022Type:Original ArticleAuthors:Pascalle Sousa Rocha, Fernando Luiz Affonso Fonseca, David Feder, Luiz Elidio Gregório, Joserlan Nonato Moreira, Luis Rafael Leite Sampaio, Glaucia Luciano da Veiga, Fulvio Alexandre Scorza, Beatriz da Costa Aguiar Alves, Thais Gascón, Carla Alessandra Scorza, and Fabio Ferreira Perazzo Author(s) affiliations:Pascalle Sousa Rocha1,3, Fernando Luiz Affonso Fonseca2,7, David Feder7, Luiz Elidio Gregório2, Joserlan Nonato Moreira3, Luis Rafael Leite Sampaio4, Glaucia Luciano da Veiga7, Fulvio Alexandre Scorza5,6, Beatriz da Costa Aguiar Alves7, Thais Gascón7, Carla Alessandra Scorza5,6, Fabio Ferreira Perazzo1,2 1Departamento de Morfologia e Fisiologia, Centro Universitário FMABC. Santo André, BRASIL. 2Departamento de Ciências Farmacêuticas. Universidade Federal de São Paulo. Diadema, BRASIL. 3Departamento de Saúde. Instituto Federal da Paraíba. Paraíba, BRASIL. 4Departamento de Enfermagem. Centro de Ciências Biológicas e da Saúde, Universidade Regional do Cariri. Paraíba, BRASIL. 5Centro de Neurociências e Saúde, Universidade Federal de São Paulo /UNIFESP. São Paulo, BRASIL. 6Disciplina de Neurociência. Universidade Federal de São Paulo/UNIFESP. São Paulo, BRASIL. 7Laboratório de Análises Clínicas. Centro Universitário FMABC. Santo André, BRASIL. Abstract:Objectives: Chronic wounds in patients of several diseases, especially diabetics, comprise a public health problem in Brazil. The aim of this study was evaluate the effects of topical application of 5% green propolis ointment on nonspecific chronic wounds of patients from a health unit in Cajazeiras, Paraíba. Materials and Methods: The patients were divided into two groups: 20 for the intervention group, treated with 5% green propolis ointment, and 20 participants for the control group, treated with an essential fatty acid, plus vitamins A and E, which has standard application in the Brazilian Public Service, both during 30 days. The following clinical variables were observed: complications (necrosis, crust), aspects of the skin around the lesion, appearance and amount of exudate, signs of infection, presence of pain during treatment, appearance of any complication and odor. Forty participants were surveyed from May 2017 to October 2018. Results: Most of them were women (52.5%) aging from 76 to 95 years (55%), and illiterate (77.5%). The prevalent bacteria in the wounds were Pseudomonas aeruginosa, and most of the sensitive antibiotics were aminoglycoside. In the control group, two of eight participants evaluated on the first day remained infected, whereas, in the group treated with green propolis ointment, all nine patients had infection cleared, with reduction of pain, 81.8% decrease of lesions with purulent exudate, and 73.4% debridement of devitalized tissue. Conclusion: These results confirm the potential of the green propolis ointment as a debridement, bactericide, and the ability to inhibit the growth of microorganisms, and adsorb odors. Keywords:Chronic wound, Clinical trial, Propolis, Treatment, Wound infectionView:PDF (148.9 KB)