Abstract
Cardiac magnetic resonance (CMR) spin-lattice relaxation time (T1) may be influenced by pathologic conditions due to changes in myocardial water content. We aimed to validate the principle and investigate T1 mapping at rest and adenosine stress to differentiate ischemic and infarcted myocardium from controls. Patients with suspected coronary artery disease who underwent CMR were prospectively recruited. Native rest and adenosine stress T1 maps were obtained using standard modified Look-Locker Inversion-Recovery technique. Among 181 patients included, T1 values were measured from three groups. In the control group, 72 patients showed myocardium with a T1 profile of 1,039 ± 75 ms at rest and a significant increase during stress (4.79 ± 3.14%, p < 0.001). While the ischemic (51 patients) and infarcted (58 patients) groups showed elevated resting T1 compared to controls (1,040 ± 90 ms for ischemic; 1,239 ± 121 ms for infarcted, p < 0.001), neither of which presented significant T1 reactivity (1.38 ± 3.02% for ischemic; 1.55 ± 5.25% for infarcted). We concluded that adenosine stress and rest T1 mapping may be useful to differentiate normal, ischemic and infarcted myocardium.
Highlights
Cardiac magnetic resonance (CMR) spin-lattice relaxation time (T1) may be influenced by pathologic conditions due to changes in myocardial water content
Conventional CMR performed during stress perfusion and late gadolinium enhancement (LGE) differentiates myocardial area of ischemia and scar based on perfusion defect revealed by contrast bolus during adenosine stress and hyperintensity at the late stage after contrast injection, respectively[7]
This study has validated the principle of using native T1 at rest and during adenosine stress to differentiate area of myocardial ischemia and infarction from control in suspected coronary artery disease (CAD)
Summary
Cardiac magnetic resonance (CMR) spin-lattice relaxation time (T1) may be influenced by pathologic conditions due to changes in myocardial water content. We aimed to validate the principle and investigate T1 mapping at rest and adenosine stress to differentiate ischemic and infarcted myocardium from controls. 72 patients showed myocardium with a T1 profile of 1,039 ± 75 ms at rest and a significant increase during stress (4.79 ± 3.14%, p < 0.001). We concluded that adenosine stress and rest T1 mapping may be useful to differentiate normal, ischemic and infarcted myocardium. Cardiac magnetic resonance (CMR) is one of the standard imaging techniques for assessment of myocardial ischemia and s car[6]. The aim of this study was to validate and assess this principle of native CMR T1 mapping at rest and during adenosine stress (scan protocol in Fig. 1 and imaging sequence parameters in Table 1) to differentiate control, ischemic, and infarcted myocardium in suspected CAD patients
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