Abstract
We report a patient with overlap syndrome (systemic sclerosis (SSc) and polymyositis (PM)). The heterogeneous nature of systemic sclerosis may lead to a great diversity in the clinical presentation of the disease. With this case report we aim to demonstrate clinical manifestations of systemic sclerosis and polymyositis in an overlap-syndrome, with support from antibody profile and laboratory data.
Highlights
We report a patient with overlap syndrome (systemic sclerosis (SSc) and polymyositis (PM))
These antibodies are found in polymyositis, dermatomyositis and systemic sclerosis, usually in overlap syndromes with varying predominating symptoms [16,17,18]
The patient presented in this case report was initially diagnosed with systemic sclerosis on the basis of cutaneous and pulmonary findings in addition to the ANA-profile
Summary
We report a patient with overlap syndrome (systemic sclerosis (SSc) and polymyositis (PM)). The heterogeneous nature of systemic sclerosis may lead to a great diversity in the clinical presentation of the disease. With this case report we aim to demonstrate clinical manifestations of systemic sclerosis and polymyositis in an overlap-syndrome, with support from antibody profile and laboratory data. In HRCT (high definition computer tomography) fibrosis was found in both lungs peripherally in the lower posterior lobes. The most exacerbated patches of fibrosis were present in the eighth segment of the lung and the lung uvula These changes drew upwards in the distal segments of the subsegmental bronchi and the diaphragm. Based on the clinical features and laboratory findings, a diagnosis of systemic scleroderma (SSc) was given. A nailfold videocapillaroscopy (NVC) revealed an acute SSc pattern with changes characteristic for polymyositis (PM) (Figure 2)
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