Clinical Aspects of Neurotransplantation of Embryonal Brain Tissue

Abstract

Experiments have shown that the transplantation of nervous brain tissue enables the regeneration of morphologic, connecting, and biochemical changes in model animals (Bjorklund et al., 1980). They have determined suitable anatomic sites for iransplantation and also the conditions of survival are known. In 1985 Dr. Madrazzo from Mexico transplanted embryonal brain tissue from the mesencephalon of the substantia nigra area into the caudate nucleus of a parkinsonian patient (Madrazzo et al., 1985). Embryonal tissue of the mesencephalon was transplanted stereotactically (Hitchcock et al, 1989). In our department transplantations of mesencephalon embryonal brain tissue stereotactically in parkinsonian patients were performed in 1989 (Sramka et al., 1990). Transplantation of embryonal brain tissue—striatum in Huntington’s chorea—via open neurosurgery and via stereotactic technique was performed in 1990 (Molina et al., 1991).