Clinical Approach to a Patient with Elevated Serum Tryptase: Implications of Acute Versus Basally Elevated Levels

Jonathan J Lyons,Lawrence B Schwartz

doi:10.1007/978-3-030-27820-5_3

Clinical Approach to a Patient with Elevated Serum Tryptase: Implications of Acute Versus Basally Elevated Levels

Jonathan J Lyons, Lawrence B Schwartz

https://doi.org/10.1007/978-3-030-27820-5_3

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Publication Date: Dec 2, 2019

Citations: 3

Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Virginia Commonwealth University

#Elevated Serum Tryptase Levels #Elevated Serum Tryptase + Show 8 more

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Abstract

Measurement of tryptase is a valuable tool in the evaluation of patients with mast cell-related disorders and reactions. Recent advances in our understanding of a common genetic cause underlying elevated basal serum tryptase levels in the general population have provided additional context to evaluate patients with elevated serum tryptase levels. This chapter will provide an overview of tryptase, inherited and acquired causes for basal elevations of serum tryptase, and clinical applications of this biomarker in diagnosis and risk stratification of patients.

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