Abstract
Bee venom is a complex natural mixture with various pharmaceutical properties. Among these properties, its peptides and enzymes have potential medical therapy for pain relief and inflammation. In clinical settings, this therapy has been used widely to treat diseases by injecting into acupoints. In this article, we have conducted various research from PubMed, Cochrane Library, and Clinical Key from inception of July 2020. The results revealed that bee venom therapy has been reported effective in anti-inflammatory, antiapoptosis, and analgesic effects. Moreover, bee venom acupuncture has been commonly used for clinical disorders such as Parkinson disease, neuropathic pain, Alzheimer disease, intervertebral disc disease, spinal cord injury, musculoskeletal pain, arthritis, multiple sclerosis, skin disease and cancer.
Highlights
Bee venom (BV) is a complex natural mixture produced by Apis mellifera, an European honey bee [1,2]
Research has proven that regulatory T cells (Treg) can alleviate the have found that phospholipase A2 (PLA2), which makes up 10%–12% of dry BV [3], has an immunomodulatory effect
To investigate which of these compounds, BV acupuncture (BVA) (1 mg/kg), melittin (0.5 mg/kg), and PLA2 (0.12 mg/kg), performed best analgesic effect when injected into ST36; the results demonstrated that melittin was the strongest analgesic among all [53]
Summary
Bee venom (BV) is a complex natural mixture produced by Apis mellifera, an European honey bee [1,2]. It is composed of different peptides, proteins, and bioactive components, including melittin, phospholipase A2 (PLA2), and apamin [3]. These components have various pharmaceutical properties, including anti-inflammatory, antinociceptive [4,5], antiapoptosis, antiarthritic [6], and anticancer effects [1,2,7]. We will focus on its possible molecular mechanisms and clinical applications with respect to neural system diseases [24], musculoskeletal disease [25,26], autoimmune disease [2,8], skin disease [22,23], and cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
