Abstract
BackgroundBackground: Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years. Little is known about the feasibility of Microwave ablation (MWA) for benign breast lesion treatment. The primary aim of this prospective study was to evaluate the safety and efficiency of MWA as a potential therapeutic option for benign breast lesions in a single-center cohort study.MethodsWomen with possibly benign breast lesions based on an ultrasound (US) assessment who were scheduled to undergo MWA between November 2014 to July 2018 were included in the study. The patients underwent conventional US to measure the size of the lesion, Doppler US to assess the vascularity of the lesion, elastography to evaluate the stiffness of the mass, core needle biopsy of suspicious lesions, contrast-enhanced US to help determine the treatment plan and eventually MWA of the lesion. Lesions were followed at one, three, six, twelve and eighteen months after treatment to with the same imaging modalities.ResultsA total of 314 women aged 17 to 69 years old (mean = 36.9 ± 9.9 years) with 725 benign breast lesions (mean of maximum diameter = 10.86 ± 5.40 mm) were included. The frequency of palpable mass, pain and nipple discharge significantly decreased after treatment. Complete ablation rate was 97.8%, immediately after ablation, which increased to 100% after supplementary ablation of the 15 cases with incomplete ablation. Blood flow classification and lesion’s volume also showed a significant decrease, while both volume reduction ratio and disappearance rate significantly increased following treatment. The elasticity score of the lesions showed fluctuations across different follow-up intervals. None of the patients experienced major complications and the 1% who had mild symptoms were successfully treated.ConclusionMWA treatment is shown to be safe and efficient and has the potential to be considered as an alternative first line treatment for benign breast lesions.
Highlights
Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years
Microwave ablation (MWA) has been shown to have a higher efficiency in heating the target tissue compared to radiofrequency ablation (RFA), which is due to the difference in heating mechanisms of the two techniques; microwave heating is a result of dielectric heating, while radiofrequency is resulting from Joule heating, in which the tissue is heated through friction and thermal conduction from the electrode and it is strongly influenced by the tissue’s impedance
The present study investigated the outcomes of US-guided MWA treatment in patients with benign breast lesions to assess the feasibility and efficiency of this method
Summary
Background: Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years. The primary aim of this prospective study was to evaluate the safety and efficiency of MWA as a potential therapeutic option for benign breast lesions in a single-center cohort study. Benign breast lesions such as fibroadenoma and mammary adenosis are amongst the most common diseases in adult women, usually presenting as multiple and bilateral masses [1, 2]. The present study investigated the outcomes of US-guided MWA treatment in patients with benign breast lesions to assess the feasibility and efficiency of this method
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
