Abstract
Objectives: Precise monitoring of haemostasis is of utmost importance in ventricular assist device recipients. In clinical routine thromboplastin time (PTT) and international normalized ratio (INR) are used for evaluation of coagulation capacity and adjustment of anticoagulation therapy. In detail, PTT represents endogenous homeostasis and INR represents the exogenous homeostasis but both only reflect 2 percentage of the total plasmatic thrombin generation. During the past decade alternative methodological approaches were designed to address the total thrombin generation (TG) as a measure for true plasmatic coagulation. The present study aimed to investigate the course of thrombin generation in VAD recipients in intensive care unit. Furthermore, the study reveals a more detailed few of the disturbed haemostasis and its correlation with bleeding and thromboembolism events.
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