Abstract
To explore the associations of serum tumor associated material (TAM) with other common tumor markers like carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen19-9 (CA19-9) and its clinical application in non-small cell lung cancer (NSCLC) patients. A total of 87 patients were enrolled into this study, all with histologically or cytologically confirmed NSCLC. With the method of chemical colorimetry, the level of TAM was determined and compared, while chemiluminescence was used to measure the levels of common tumor markers. The level of TAM decreased after chemotherapy compared with before chemotherapy when CT or MRI scans showed disease control. Furthermore, it increased when disease progressed and there was no statistically significant difference in monitoring of TAM and common tumor markers (P>0.05). Detecting TAM in NSCLC patients has a higher sensitivity and specificity, so it can be used as an indicator for clinical monitoring of lung cancer chemotherapy.
Highlights
Altered glycosylation patterns are a hallmark of tumor phenotype
Detecting tumor associated material (TAM) in non-small cell lung cancer (NSCLC) patients has a higher sensitivity and specificity, so it can be used as an indicator for clinical monitoring of lung cancer chemotherapy
The aim of this study was to explore the application of serum tumor associated material (TAM) before and after chemotherapy in non-small cell lung cancer (NSCLC) patients
Summary
Altered glycosylation patterns are a hallmark of tumor phenotype. This phenomenon was first described by Meezan et al in 1969 with the demonstration that healthy fibroblasts have smaller membrane glycoproteins than their transformed counterparts (Meezan et al, 1969). Objective: To explore the associations of serum tumor associated material (TAM) with other common tumor markers like carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen19-9 (CA19-9) and its clinical application in non-small cell lung cancer (NSCLC) patients. It increased when disease progessed and there was no statistically significant difference in monitoring of TAM and common tumor markers (P>0.05).
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