Clinical application of nerve growth factor delivery release system on treatment of peripheral nerve relaxation

Abstract

Objective To prepare nerve growth factor delivery release system , and explore its clinical effects on peripheral nerve relaxation. Methods Thirty six patients of patients with median nerve injuries in the forearm and wrist were strictly followed up and accepted neurolysis after 3 months in the 98th Hospital of PLA from March 2011 to May 2013. The patients were randomly divided into group A (18 patients) and B group (18 patients). The NGF(total 30 mL, concentration of 8.12 mg/mL) was used to partial release by using the homemade delivery release system in group A, the same amount of NGF was partial injected to Gelatin sponge surrounding peripheral nerve in group B. All patients respectively underwent neural electrophysiological examination after 8 weeks. The somatosensory evoked potentials (SEP) and compound muscle action potentials (CMAP) between different groups were compared, and motor nerve conduction velocity (NCV) was also analyzed. The sensory and motor function evaluation score of British Medical Research Council(BMRC) were performed after 24 weeks. Results The peak latency of the SEP after 8 weeks in A and B groups were (20.56±3.50)ms and(32.25±4.61)ms, respectively. The volatility were (17.22±3.46)μV and (9.90±1.37)μV, respectively. The peak latency of the CMAP after 8 weeks in A and B groups were (2.10±0.37)ms and(4.31±0.66)ms, respectively. The volatility were (810.9±108.16)μV and(506.61±67.50)μV, the NCV were (41.21±3.34)m/s and(30.68±2.21)m/s, respectively. Compared with the group B, the peak latencies of the SEP and CMAP were shortened significantly and the Volatility was increased significantly in group A, the NCV was faster in group A(all P values<0.01). The good rate of the A and B groups in BMRC sensory function score were 16/18 and 12/18, respectively. The good rate in BMRC motor function score were 14/18 and 9/18, respectively. The good rate in group A was higher than that in group B(all P values<0.05) . Conclusions Nerve growth factor delivery delivery system is effective in promoting the recovery of neurological function after neurolysis , and can be used as a supplementary means of nerve damage in the later stage. It is simple to operate and worthy of promoting. Key words: Peripheral nerve injuries; Nerve growth factor; Delivery release system; Neurolysis