Clinical application of milbemycin D as a prophylactic agent against Dirofilaria immitis infection in dogs: sensitivity for the drug in rough-coated collies.

Abstract

To evaluate sensitivity owing to breed idiosyncrasy for milbemycin D (Milbe), 5 rough-coated collies and 7 Shiba dogs were treated with Milbe at a dose of 1.0mg/kg, 2.5mg/kg and 5.0mg/kg orally for 10 consecutive days. In the 5.0mg/kg dose of the collie group, neurologic signs such as arrhythmia, salivation, mydoriasis, staggering, recumbency, lethargy and so on occurred in 4 of 5 dogs after the 1st administration, and showed intermittently or continuously during the trial. The intensity of the neurologic signs was different in the individual dog and with the day of administration. The affected dogs recovered without treatment within 24 hr after the administration and no dog died.