Abstract
Clinical application of mesenchymal stem cells for cartilage regeneration
Highlights
Cartilage offers high compressive force and covers the surfaces of synovial joints[1]
In 2017, the group tried to compare the cartilage regeneration results between BMSCs and bone marrow concentrate (BMC). They mixed porcine cartilage, SDSCs fragments with BMSCs or BMC to form different constructs
Results showed that BMC-containing constructs could stimulate chondrogenesis and BMSCs-containing constructs could assist in extracellular matrix (ECM) synthesis[75]
Summary
Cartilage offers high compressive force and covers the surfaces of synovial joints[1]. A BMSCs/collagen gel composite for cartilage repair clinical trial in Taiwan was conducted in 2008, and results suggested that there was an improvement in IKDC and MRI score at 9-years of follow-up. Published their results on the use of autologous BMSCs for OA treatment (n = 4), where they injected about 8 to 9 × 106 cells into patients’ knee cavity.
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