Abstract
BackgroundTo reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted. Numerous candidates have been proposed; however, near-infrared spectroscopy (NIRS) with multi-channel probes and a dexamethasone/corticotropin-releasing hormone (DEX/CRH) test are still surviving for practical demand. Thirty-one outpatients with depressed moods were analyzed using both biological tests.ResultsThe non-suppressors, as indicated by the DEX/CRH test, exhibited a high severity on the Hamilton Depression Scale and severe anxiety on the State Trait Anxiety Scale. In addition, a unique response was identified via NIRS in the same group suggested by the DEX/CRH assessment.ConclusionsThe results obtained from these biological tests did not fit well with the category defined by operative diagnostic criteria, such as the Diagnostic and Statistical Manual of Mental Disorders or The International Classification of Diseases. Thus, it is critical that the utility evaluations of candidate biomarkers not be assessed by comparisons with the categorized criteria for a specific psychiatric disorder.Trial registration UMIN000013214, Registered 21 February 2014
Highlights
To reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted
The association between the reaction in the DEX/ CRH test and the severity of depression determined by the Hamilton depression rating scale (HAMD) assessment was investigated
We compared the results of the near-infrared spectroscopy (NIRS) assessment with the reaction of the dexamethasone/corticotropin-releasing hormone (DEX/CRH) test
Summary
To reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted. A depressed mental state is caused by non-specific mental disorders, such as a mood disorder, schizophrenia, substance abuse, a personality disorder, or nearly every psychiatric condition. If it is more prolonged than expected, several types of costs related to individuals with depressed moods will increase. A recent analysis indicated a 21.5 % cost increment, $173.2 billion (2005) to $210.5 billion (2010), within 5 years, and this cost will be further increased [9] Another analysis with regard to the global DALY (disability-adjusted life year) indicated that the cost associated with depression would represent the primary cost of all disorders, including physical disorders, in 2030, and it ranked 3rd in 2004 These analyses have provided warnings regarding the importance of depression prevention. To perform effective treatment, a precise assessment based on scientific data comprises a key factor
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
