Abstract
BackgroundThis study aimed to investigate the clinical significance of contrast enhanced ultrasound (CEUS) in diagnosis of benign prostatic hyperplasia (BPH) through comparing CEUS parameters between BPH and normal person.MethodsA retrospective study of sixty BPH patients (aged 73.5 ± 20.5 years old) and thirty normal controls without prostate diseases (aged 75.3 ± 19.7 years old) who had accepted CEUS detection were performed. Time-intensity curves were obtained for all tests in regions of interest. Images were processed using ACQ software and the following parameters were obtained: arrival time (AT), peak intensity (P), time to peak (TP), area under the curve (AUC), mean transit time (MTT) and extinction time (ET). Differences in inner and outer gland of prostate between BPH and the normal tissue were evaluated.ResultsThere was a clear boundary between the inner and outer gland of BPH prostate. AT, TP, MTT, ET and P in BPH outer gland were significantly higher than the control group. In inner gland, MTT, ET, AUC and P were also significantly higher than the controls. The accurate rate to diagnose BPH using CEUS was 95.6%, and the sensitivity and specificity were 95.0% and 96.7%, respectively.ConclusionsAmong these significantly changed parameters, the increases of MTT, ET and AUC in inner gland and AT, TP in outer gland were most likely related to BPH. These parameters provide an objective visual assessment to diagnosis of BPH.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4852383312229155
Highlights
This study aimed to investigate the clinical significance of contrast enhanced ultrasound (CEUS) in diagnosis of benign prostatic hyperplasia (BPH) through comparing CEUS parameters between BPH and normal person
A dramatic rise in BPH is found in males over the age of 40 and the incidence reached to 50% and 80% in the age of 60 and 80, respectively [2]
Research object Sixty BPH patients treated by CEUS at Central Hospital of Shanghai Jiading District from May 2009 to October 2012 were studied retrospectively
Summary
This study aimed to investigate the clinical significance of contrast enhanced ultrasound (CEUS) in diagnosis of benign prostatic hyperplasia (BPH) through comparing CEUS parameters between BPH and normal person. Prostate is an abundant blood supply organ and divided into inner and outer gland [3]. The inner gland of Nowadays, ultrasonic examination is the most common diagnostic method in BPH. The inner and outer gland of prostate in BPH patients can be clearly observed. In CEUS, contrast agent is used to enhance the contrast of tissues and blood within the body in medical imaging. Contrast agent significantly increases the diagnostic potential of CEUS and makes it possible to visualize tumor vascularization [7,8]. There are few studies on comparison of CEUS in normal prostate and BPH
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