Abstract
The Chandler's loop method has been widely used for producing thrombus in vitro and evaluating thrombolytic agents. In the present study, the Chandler's loop method was used for evaluation of thrombic and thrombolytic states in 50 normal subjects and 20 patients with cerebral thrombosis. In normal subjects, the experimental clot showed increase in weight with progression of age, while thrombolytic effect showed little correlation with the age. The clot weight from stroke patients immediately after the onset of accident varied from twice of, to less than, the weight from normal subjects, and thrombolysis in vitro by Urokinase tended to occur more easily in larger clots. Correlation between decrease in thrombus weight and increase in thrombolytic rate were observed in convalescent stage of the disease. Within 2 weeks after discontinuation of Urokinase treatment, an acute rebound rise in thrombus weight was frequently seen. Experimental thrombus formation and thrombolytic rate in the present study might be correlated to the homeostatic balance in the normal and the diseased and reveal some aspects of pathophysiological mechanisms in thrombosis.
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