Abstract
Implant related infection is one of the most frequent complications in orthopaedic and trauma surgery. Local antibiotic treatment strategies are becoming part of the prevention and treatment methodology for this fearful complication. To date, there are two coatings available on the market, both with a polylactic acid base. Current evidence supports the use of these types of coatings in the prophylaxis of periprosthetic infections and fracture-related infections. However, their therapeutic use has been less investigated. The purpose of this article is to summarise recent evidence relating to the clinical application of antibacterial hydrogels and coatings in orthopaedic and traumatology surgery and indicating which future applications may benefit from it.
Highlights
Implant-related infection is one of the most frequent complications in orthopaedic and trauma surgery
Such infections can lead to an increase in hospitalization costs, of up to seven times the hospitalization costs of a non-infected patient [6]
Romanò et al showed a significant reduction in the incidence of periprosthetic infections in the treatment group compared to the control group
Summary
Implant-related infection is one of the most frequent complications in orthopaedic and trauma surgery. The first is a biocompatible hydrogel, the Defensive Antibacterial Coating (DAC—Novagenit, Mezzolombardo, Italy) composed by covalently bound hyaluronic acid and polylactic acid capable of forming a physical barrier against bacterial adhesion by releasing high concentrations of the surgeon’s chosen antibiotic or antifungal [9,10]. It subsequently undergoes complete reabsorption via hydrolytic degradation within 72 h, completely releasing the antibiotic contained within it. Antibiotics are added, upon surgeon’s responsibility, by a list of mixable antibiotics
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