Abstract
Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and integrated PET/CT have been increasingly used in patients with head and neck cancers. 18F-FDG PET and PET/CT can provide valuable information during initial staging, especially in the nodal staging of the neck and in the detection of distant metastases or synchronous second primary malignancies. They are also helpful in identifying a primary tumor in patients with cervical lymph node metastases from an unknown primary tumor. PET and PET/CT are useful for the evaluation of treatment response in patients undergoing radiotherapy or chemoradiotherapy. PET and PET/CT are accurate in the detection of recurrent disease and can be used in patients at high risk or with clinically suspected recurrence. In addition, PET and PET/CT can provide independent prognostic information with regard to relapse-free survival and overall survival. The role of PET/CT in the radiotherapy planning has been under active investigation recently.
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