Abstract
Abstract Clinical and technical aspects of photodynamic therapy are reviewed with emphasis on the treatment of skin tumors as examples of superficial lesions with perpendicular illumination and prostate cancer as an example of deeply embedded tumors requiring interstitial intervention. The field is surveyed with a special perspective based on studies for more than 20 years on the clinical and technical aspects of research pursued in an interdisciplinary setting at the Lund University Medical Laser Center. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose is highlighted. Examples of fluorescence demarcation to guide the treatment inclusion zone in non‐melanoma skin malignancies are given. A multiple fiber interstitial and interactive procedure to deliver the required therapeutic light dose based on measured light fluence, sensitizer, and oxygen concentration levels in the tumor is presented. Application to the eradication of prostate cancer is illustrated.
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