Abstract
The ‘Arthropathy of Down syndrome’ was first described in 1984. Three decades on we still have limited literature on the clinical and radiological features of this arthritis, despite the fact that it is thought to be 3-6 times more common than JIA in the general paediatric population. Down’s Arthropathy (DA) is rarely recognised at onset, and remains under-diagnosed and largely under-reported in this population group. Ireland has one of the highest Trisomy 21 birth rates in Europe (1/547), & therefore provides an ideal setting for such a study. Research Q's - 1. What are the clinical & radiological features of DA? 2. Is DA missed, leading to a delay in dx?
Highlights
The ‘Arthropathy of Down syndrome’ was first described in 1984
To date, 370 children with Trisomy 21 have enrolled in the study, 56% Male. 17 new cases of Down’s Arthropathy (DA) have been detected, only three (17.6%) of which were referred with suspected arthritis
28 children with DA attend the National Centre for Paediatric Rheumatology (NCPR) for management of their arthritis, the largest cohort ever reported in the literature
Summary
The ‘Arthropathy of Down syndrome’ was first described in 1984. Three decades on we still have limited literature on the clinical and radiological features of this arthritis, despite the fact that it is thought to be 3-6 times more common than JIA in the general paediatric population. Down’s Arthropathy (DA) is rarely recognised at onset, and remains under-diagnosed and largely under-reported in this population group. Ireland has one of the highest Trisomy 21 birth rates in Europe (1/547), & provides an ideal setting for such a study. What are the clinical & radiological features of DA? 2. Is DA missed, leading to a delay in dx?
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