Abstract
Recently, the transcription factor SOX11 has gained extensive attention as a diagnostic marker in a series of cancers. However, to date, the possible roles of SOX11 in breast cancer has not been investigated. In this study, immunohistochemical staining for SOX11 was performed for 116 cases of breast cancer. Nuclear SOX11 was observed in 42 (36.2%) and cytoplasmic SOX11 in 52 (44.8%) of breast cancer samples. Moreover, high expression of cytoplasmic and nuclear SOX11 was associated with clinicopathological factors, including earlier tumor grade, absence of lymph node metastasis and smaller tumor size. Kaplan-Meier survival curves demonstrated high nuclear SOX11 expression to be associated with more prolonged overall survival than those with low expression and it could be an independent predictor of survival for breast cancer patients. It is worthwhile to note that cytoplasmic SOX11 was not correlated with prognosis of breast cancer patients. These data suggest the possibility that nuclear SOX11 could be as a potential target for breast cancer therapy.
Highlights
As the most common malignancy in women in the world, the incidence of breast cancer had increased in recent years (Khan et al, 2014)
Kaplan-Meier survival curves demonstrated high nuclear SOX11 expression to be associated with more prolonged overall survival than those with low expression and it could be an independent predictor of survival for breast cancer patients
For the first time, we revealed that nuclear SOX11 expression was associated with better prognosis of breast cancer patients
Summary
As the most common malignancy in women in the world, the incidence of breast cancer had increased in recent years (Khan et al, 2014). Taking into account the limited effective methods in treatment of breast cancer, identification of more promising markers related with outcome of patients is of great importance. These biomarkers would facilitate finding more effective therapies for breast cancer patients. It was noted that SOX11 expression decrease the growth and invasion capacity of nasopharyngeal carcinoma cells (Zhang et al, 2013). These results suggested SOX11 could be as a tumor suppress gene. To date, the possible roles of SOX11 in breast cancer has not been investigated
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