Abstract
This prospective observational study was conducted to investigate epidemiological and clinical features of neonates with congenital syphilis at the Neonatal Center of Vietnam National Children’s Hospital from January 2018 to June 2021. Twenty-nine patients were diagnosed with congenital syphilis by Treponema Pallidum hemagglutination assay (TPHA) reaction. The most common manifestations of congenital syphilis were desquamation (41.4%), hepatomegaly (31.4%), splenomegaly (37.9%), and early jaundice (24.1%). Thrombocytopenia, anemia, elevated liver enzymes, and conjugated hyperbilirubinemia were common laboratory findings of congenital syphilis. The mortality rate of congenital syphilis was 13.7%. Parental syphilis status of 51.9% of neonates born with congenital syphilis was unknown. Thus, a systematic launch of a screening program for syphilis for all pregnant women is critical.
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