Abstract
Tumour necrosis factor (TNF) is the dominant mediator of the cytokine cascade that causes inflammation and joint destruction in rheumatoid arthritis (RA). A new class of agent under investigation, the biological TNF inhibitors, inhibit the activity of TNF. Recombinant human TNF receptor p75 Fc fusion protein (TNFR:Fc; etanercept) blocks the activity of the cytokine TNF. Etanercept (Enbrel™) was recently approved by the Food and Drug Administration for the treatment of RA. Etanercept is a genetically engineered recombinant soluble TNF receptor fusion protein that binds to TNF body and inhibits its biologic action; it is the first biotechnology product approved for the treatment of RA. Remarkable progress has been achieved in the treatment of RA with the development of TNF antagonists. Recent clinical trials have improved our understanding of the major role played by the cytokine TNF in provoking joint inflammation in RA.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
