Abstract
Non-motor symptoms are an essential manifestation of the clinical picture of Parkinson's disease (PD). This literature review is devoted to the study of recent advances in the field of clinical and pathophysiological aspects of the non-motor manifestations of Parkinson's disease.Aim. The aim was to study and generalize the wide range of non-motor manifestations of PD and their features in this pathology, and to reveal the pathophysiological link between motor and non-motor manifestations of the disease and the role of the neurodegenerative process in the clinical picture of PD.Materials and methods. Keywords (Parkinson's disease, non-motor symptoms, apathy, anxiety, depression, sleep disorder, pain) search in the Web of Science, Core Collection, Scopus, Pubmed databases.Results. Knowledge about the presence of PD non-motor symptoms, characteristics of their manifestations improve their diagnosis and help to choose the correct treatment strategy. This survey comprises nonmotor manifestations of PD, such as: mood disorders (apathy, anxiety, depression), impulse control disorders (dopamine disregulation syndrome), sleep disorders (insomnia, excessive daytime sleepiness, bouts of sleepiness, conduct disorder in REM phase of sleep), autonomic disorders (constipation, enuresis, thermoregulatory dysfunction, cardiovascular disorders, orthostatic hypotension), and cognitive impairment.
Highlights
Non-motor symptoms are an essential manifestation of the clinical picture of Parkinson's disease (PD)
This literature review is devoted to the study of recent advances in the field of clinical and pathophysiological aspects of the non-motor manifestations of Parkinson's disease
Zhalsanova Irina Zh., Post-Graduate Student, Laboratory of Population Genetics, Research Institute of Medical Genetics, Tomsk National Research Medical center (NRMC), RAS, Tomsk, Russian Federation
Summary
Клинические и патофизиологические аспекты немоторных проявлений болезни Паркинсона. Никитина М.А.1, Жукова Н.Г.1, Брагина Е.Ю.2, Алифирова В.М.1, Жукова И.А.1, Гомбоева Д.Е.2, Колупаева Е.С.1, Жалсанова И.Ж.2. Íåìîòîðíûå ñèìïòîìû ÿâëÿþòñÿ íåîòúåìëåìûì ïðîÿâëåíèåì êëèíè÷åñêîé êàðòèíû áîëåçíè Ïàðêèíñîíà (ÁÏ). Îáçîð ëèòåðàòóðû ïîñâÿùåí èçó÷åíèþ ïîñëåäíèõ äîñòèæåíèé â îáëàñòè êëèíè÷åñêèõ è ïàòîôèçèîëîãè÷åñêèõ àñïåêòîâ íåìîòîðíûõ ïðîÿâëåíèé áîëåçíè Ïàðêèíñîíà. Ïîèñê ïî êëþ÷åâûì ñëîâàì (áîëåçíü Ïàðêèíñîíà, íåìîòîðíûå ïðîÿâëåíèÿ, àïàòèÿ, òðåâîãà, äåïðåññèÿ, ñîíëèâîñòü, áîëü) â áàçàõ äàííûõ Web of Science, Core Collection, Scopus, Pubmed ïî çàðóáåæíûì æóðíàëàì. Äàííûé ëèòåðàòóðíûé îáçîð îõâàòûâàåò òàêèå íåìîòîðíûå ïðîÿâëåíèÿ ÁÏ, êàê ðàññòðîéñòâà íàñòðîåíèÿ (àïàòèÿ, òðåâîãà, äåïðåññèÿ), ðàññòðîéñòâà èìïóëüñèâíîãî êîíòðîëÿ (äîôàìèíîâûé äèçðåãóëÿöèîííûé ñèíäðîì), ðàññòðîéñòâà ñíà (áåññîííèöà, ÷ðåçìåðíàÿ äíåâíàÿ ñîíëèâîñòü, ïðèñòóïû ñîíëèâîñòè, ðàññòðîéñòâî ïîâåäåíèÿ â ôàçó ñíà ñ áûñòðûì äâèæåíèåì ãëàç), âåãåòàòèâíûå íàðóøåíèÿ (êîíñòèïàöèÿ, íåäåðæàíèå ìî÷è, òåðìîðåãóëÿòîðíàÿ äèñôóíêöèÿ, êàðäèîâàñêóëÿðíûå íàðóøåíèÿ, îðòîñòàòè÷åñêàÿ ãèïîòåíçèÿ) è íàðóøåíèÿ êîãíèòèâíîé ñôåðû. Êëþ÷åâûå ñëîâà: áîëåçíü Ïàðêèíñîíà, íåìîòîðíûå ïðîÿâëåíèÿ, àïàòèÿ, òðåâîãà, äåïðåññèÿ, ñîíëèâîñòü, áîëü. Àâòîðû äåêëàðèðóþò îòñóòñòâèå ÿâíûõ è ïîòåíöèàëüíûõ êîíôëèêòîâ èíòåðåñîâ, ñâÿçàííûõ ñ ïóáëèêàöèåé íàñòîÿùåé ñòàòüè.
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