Clinical and pathological observations of retroperitoneal paraganglioma in 32 cases

Abstract

Abstract Objective The aim of the study was to investigate the clinical manifestations, pathologic features, differentiation, and diagnosis of retroperitoneal paraganglioma. Methods The clinical manifestations, histopathologic morphology, immunohistologic features, treatment, and prognosis were analyzed in 32 cases of retroperitoneal paraganglioma, and the literature was reviewed. Results Low back pain was the main symptom of retroperitoneal paraganglioma, and patients often presented with increased blood pressure. Blood vessels were abundant in the neoplasm of retroperitoneal paraganglioma, and pathologic diagnosis showed that the cells of tumors were rich in cytoplasm, and some were basophilic. Immunohistochemical study showed that CgA, Syn, S-100, and Ki-67 (2%-30%) were expressed, while Melan-A and CK were not. The patients were treated with surgical resection. Thirteen cases were followed up, and no recurrence or metastases have been observed. Conclusion The diagnosis of retroperitoneal paraganglioma should be confirmed by morphologic features and immunophenotype. Patients should be followed-up due to the potential for malignancy.