Abstract
胰腺导管内嗜酸性乳头状肿瘤（IOPN）是胰腺导管内乳头状黏液性肿瘤（IPMN）的亚型之一，具有与IPMN相似的临床表现和影像学特征。IOPN常见于胰头部，大体表现为囊腔内充满红色或褐红色的质软乳头，产生的黏液一般较其他类型IPMN少。组织学表现为复杂的囊内乳头状结构，肿瘤细胞具有丰富的嗜酸性颗粒状胞质而不表现明显的黏液分化。免疫组织化学特征性的表达抗线粒体抗体，此外，MUC5AC阳性，MUC1局灶阳性。分子遗传学研究结果显示，IOPN具有与其他类型IPMN不同的特征，KRAS和GNAS突变频率显著低于其他类型IPMN。目前，IOPN被认为是一种胰腺癌的癌前病变，具有进展为胰腺浸润癌的风险，但总体预后良好。总之，IOPN应该被认为是一种不同于其他类型IPMN的胰腺导管内肿瘤类型。.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Zhonghua bing li xue za zhi = Chinese journal of pathology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
