Abstract
The aim of this retrospective study is to analyze the clinical and pathological factors related to the prognosis of Chinese patients with stage Ib to IIb cervical cancer. 13 clinical pathological factors in 255 patients with stage Ib to IIb cervical cancer undergoing radical hysterectomy and systematic lymphadenectomy were analyzed to screen for factors related to prognosis. The cumulative 5-year survival of the 255 patients was 75.7%. The result of the univariate analysis suggested that clinical stage, cell differentiation, depth of cervical stromal invasion, parametrial tissue involvement, and lymph node metastasis were prognostic factors for patients with stage Ib to IIb cervical cancer (P<0.05). Compared with cases with involvement of iliac nodes, obturator nodes, or inguinal lymph nodes, cases with metastasis to the common iliac lymph nodes had a poorer prognosis (P<0.05). Cases with involvement of four or more lymph nodes had a poorer prognosis than those with involvement of three or fewer lymph nodes (P<0.05). Using multivariate Cox proportional hazards model regression analysis, non-squamous histological type, poor differentiation, parametrial tissue involvement, and outer 1/3 stromal invasion were found to be independently related to patients poor prognosis (P<0.05). Non-squamous histological type, poor cell differentiation, parametrial tissue involvement, and outer 1/3 stromal invasion are the independent poor prognostic factors for patients with stage Ib to IIb cervical cancer.
Highlights
Cervical cancer is a major global public health problem and the third worldwide leading cause of cancer death in women ( Pointreau et al, 2010)
Note: 1) comparison between 2/3 group; 4) comparison between Ia group and IIa group; 5) comparison between Ia group and IIb group; 6) comparison between IIb group and IIa group suggested that clinical stage, cell differentiation, parametrial invasion, depth of stromal invasion, and lymph node metastasis were related to the prognosis of patients with stage Ib-II b cervical cancer (P
The results of the univariate analysis in this study suggested that clinical stage, cell differentiation, depth of cervical stromal invasion, parametrial invasion, and lymph node metastasis were related to the prognosis of patients with stage Ib to II b cervical cancer
Summary
Cervical cancer is a major global public health problem and the third worldwide leading cause of cancer death in women ( Pointreau et al, 2010). Sakuragi found that there was a significant relationship between the number of lymph nodes removed and diseasefree survival in node-positive patients, the bigger the number of lymph nodes removed was,the longer diseasefree survival would be (Sakuragi, 2007), but there were no more studies to confirm the above argument. Other factors such as clinical stage, cell differentiation, histological type, parametrial tissue involvement were thought to be relevant to the prognosis of cervical cancer in many studies,but whether those factors are the independent prognostic factors needs more studies.There were few studies about the influence of uterine body involvement on prognosis of cervical cancer
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