Abstract
Tumors of mesenchymal origin are rarely reported in the pancreas. Therefore, this study characterized 17 feline non-epithelial pancreatic tumors, including clinical data, histopathology, and immunohistochemistry. Seventeen feline pancreatic tissue samples were investigated histopathologically and immunohistochemically. Selected pancreatic and inflammatory serum parameters, e.g., feline pancreatic lipase immunoreactivity (fPLI), 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR) lipase and serum amyloid A (SAA), were recorded, when available. The neoplasms were characterized as round (n = 13) or spindle (n = 4) cell tumors. Round cell tumors included 12 lymphomas and one mast cell tumor in ectopic splenic tissue within the pancreas. Lymphomas were of T-cell (n = 9) or B-cell (n = 3) origin. These cats showed leukocytosis (3/3) and increased fPLI (5/5), DGGR lipase (3/5) and SAA (4/5) values. Spindle cell tumors included two hemangiosarcomas, one pleomorphic sarcoma and one fibrosarcoma. The cat with pleomorphic sarcoma showed increased SAA value. Overall survival time was two weeks to seven months. These are the first descriptions of a pancreatic pleomorphic sarcoma and a mast cell tumor in accessory spleens within feline pancreas. Although rare, pancreatic tumors should be considered in cats presenting with clinical signs and clinical pathology changes of pancreatitis. Only histopathology can certainly distinguish solitary pancreatitis from a neoplasm with inflammation.
Highlights
Pancreatic neoplasms are rare in cats, dogs [1,2,3], and humans [4]
Spindle cell tumors were classified as two hemangiosarcomas, one pleomorphic sarcoma, and one fibrosarcoma
Clinical pathology was available for five cats with lymphoma and one cat with pleomorphic sarcoma (Table 3)
Summary
Pancreatic neoplasms are rare in cats, dogs [1,2,3], and humans [4]. Carcinoma is the most common tumor type in cats and dogs, but adenomas, sarcomas, lymphomas, unclassified tumors, and metastatic neoplasms have been described [1,2,3,5]. Pancreatic neoplasms generally cause non-specific constitutional and gastrointestinal signs such as lethargy, anorexia, weight loss, diarrhea, vomiting, abdominal pain, or palpable abdominal masses [6,7,8]. Lymphomas are common neoplasms in most domestic species. Gastrointestinal lymphoma is the most common form of lymphoma in cats and is associated with clinical presentation such as weight loss, vomiting, diarrhea anorexia, and lethargy [9]. Pancreatic involvement has been reported in only some cases and pancreas-specific blood parameters were not included in the studies [10,11,12,13]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
