Abstract
Medial calcific sclerosis (MCS) of Monckeberg a nonocclusive calcification of the media of small to medium-sized muscular arteries, may frequently occur in the prolapsed uteri. The etiology and pathogenesis of MCS is still obscure. In the present investigation, we use routine hysterectomy specimen of prolapsed uteri to investigate age distribution, and localized vasotonic effect of parity. Systemic risk factors of hypertension and diabetes mellitus on atherosclerosis as well as on arteriolosclerosis are also investigated to see if there is any association with these and MCS in the prolapsed uterus. One hundred and fifteen cases of uterine prolapse are analyzed. The occurrence rate of MCS was 53.04%(61 of 115 cases). The mean age of MCS cases is 69.8 (SD=6.4), and cases without MCS, 54.5 (n=54, SD=7.6). [T-test: t=11.72, p=0.000, 95% CI=12.71-17.89]. The percentage of MCS increases positively with each 10-year age interval starting from age 50. No MCS is found in the 23 cases aged less than 50. [Extended Mantel-Haenszel test for trend: χ2=44.766 (DF=1), P=0.000]. Thus, we note that there is significant correlation of MCS and patient age, with an increasing trend of MCS as aging process continued past the age of 50. Significant difference was noted with MCS and parity between the two groups (5.01 vs. 3.28) evidenced by Chi-square test for relationship of the parity and MCS between parity of 3 or less and more than 3 [χ2=22.924, P=0.000]. No significant relationship was found for either hypertension or DM with MCS in the prolapsed uterus. Significant uterine weight loss was detected in those with MCS, when compared with non-MCS group [T-test: t=7.048, P=0.000, 95% CI (42.29-75.37)]. Lesion of MCS is a progressive degenerative change leading to smooth muscle necrosis of the media of small to medium-sized muscular arteries and superimposed calcium deposition. Smooth muscle cell necrosis or apoptosis with evident apoptotic bodies are diffusely present in media and may also be in intima. The investigation adds support to the prevailing concept that MCS in the prolapsed uterus is correlated to prolonged localized vasotonic influence as well as the aging process.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
