Abstract
Objectives: Describe clinical features and paraclinical characteristics in 45 patients of Cryptococcal meningitis who were not HIV infected at National Hospital of Tropical Diseases - Giaiphong and Center for Tropical Diseases - Bachmai Hospital. 
 Subjects and methods: including patients aged 16 years or older diagnosed with Cryptococcal meningitis who were not HIV - infected treated at National Hospital of Tropical Diseases - Giaiphong and Center for Tropical Diseases - Bachmai Hospital from 1/2015 to 06/2020. Descriptive and retrospective and prospective cross - sectional study.
 Results: 53.3 % (24/45) were males, the mean age of the study patients was 48.9 ± 14.6 years, ranging from 21 to 79 years. The patients have comorbidities, the most common underlying disease was hepatitis and hematologic diseases 11.1%, renal diseases 8.9%, hypertension 8.9%, duration from the onset of symptoms to diagnosis 19.0 ± 15.8 days. The headache was the most common 95.6%, followed by fever 84.4%, stiff neck 80%, nausea/vomiting 62.2%, visual disturbance 13.3%, focal paralysis 8.9%. The mean protein in CSF was 1.22g/l, the mean cell count in CSF was 342/mm3. 67.4% patients had a positive culture result and 65.1% had a positive ink stainin for C. neoformans in CSF. 5.1% patients had a positive blood culture result for C. neoformans. The mean CD4 was 316.4 ± 196.0 cells/μL.
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