Clinical and oncological outcomes of open partial nephrectomy versus robot assisted partial nephrectomy over 15years.

Abstract

Partial nephrectomy (PN) is the gold standard surgical treatment for localized kidney cancer. The objective of our study was to compare clinical and perioperative outcomes of open partial nephrectomy (OPN) and robotic-assisted partial nephrectomy (RAPN). We retrospectively collected all patients who underwent PN for kidney cancer between 2007 and 2019 at two French academic urology departments. Clinical and perioperative outcomes and complications were compared between the OPN group and the RAPN group. Recurrence-free survival (RFS) and overall survival (OS) were compared using the log-rank test. We included 405 patients. The maximum follow-up time was 13.6years in the OPN group and 7.1years in the RAPN group. The OPN group was associated with more blood loss and longer hospital stay (respectively, 287ml vs. 62.1ml; p < 0.001 and 8.54days vs. 4.96days; p < 0.001). Ischemia time was shorter in the OPN group (11.4min vs. 16.9min; p < 0.001). The rate of complications during hospitalization and after discharge from hospital was higher in the OPN group (respectively, n = 51 vs. 30; p = 0.031 and n = 31 vs. 14; p < 0.001). RFS and OS were similar in both groups. In our study, RAPN has better perioperative outcomes with shorter hospital stay and less blood loss but also fewer early and late complications. However, we did not find any difference in terms of RFS and OS.