Clinical and Multi-Mode Imaging Features of Eyes With Peripapillary Hyperreflective Ovoid Mass-Like Structures.

Xiao Xie,Jitian Guan,Ge Tian,Qingjun Zhou,Xunchang Wang,Wenqi Wang,Jinyan Wang,Meng Chen,Tingting Liu

doi:10.3389/fmed.2022.796667

Abstract

PurposeTo observe and analyze the clinical and multi-mode imaging features of eyes with PHOMS, and to introduce two cases of PHOMS which underwent multi-mode imaging.MethodsRetrospective clinical observational study. A total of 26 patients (37 eyes) with hyperreflective structures surrounded by hyporeflective edges around the optic discs who were examined and diagnosed at Shandong Eye Hospital between January 2019 and June 2021 were included in the study. Among these patients, 12 were male and 14 were female. Fifteen were monocular. The average age was 39 years. All patients underwent the following examinations: Best-corrected visual acuity (BCVA), intraocular pressure examinations, slit-lamp anterior segment examinations, indirect ophthalmoscopy, visual field examinations, fundus color photography, fundus autofluorescence (FAF), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA). Some of the patients were examined with fundus fluorescein angiography (FFA). Clinical data and imaging characteristics from the OCT, OCTA, and FFA were analyzed retrospectively.ResultsWe found the hyperreflective structures surrounded by hyporeflective edges around the optic discs in 37 eyes. EDI-OCT results revealed hyperreflective structures surrounded by hyporeflective edges around the optic discs in all eyes. Typical hyperreflexia lesions occurred around the optic disc, located subretinally and above Bruch's membrane. OCTA revealed that the highly reflective perioptic material also had vascular structures.ConclusionEDI-OCT of PHOMS showed hyperreflective structures surrounded by hyporeflective edges around all of the optic discs. Infra-red photography showed temporal hyperreflexia. These characteristics can be seen in a variety of diseases and may be a relatively common feature revealed by EDI-OCT scanning. These characteristics may also be seen in elderly patients as well as children. PHOMS may be found in optic disc drusen (ODD), tilted disc syndrome (TDS), optic neuritis, ischemic optic neuropathy, and in white dot syndromes. Few patients may be developed into macular neovascularization (MNV). In order to improve the accuracy and robustness of the conclusions and provide better clinical guidance, we need to conduct more comprehensive research in the subsequent clinical work.

Highlights

Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are new imaging feature that have recently been revealed by EDI-optical coherence tomography (OCT)
In 2018, the term “PHOMS” was proposed by the Optic Disc Drusen Studies (ODDS) consortium to characterize the hyperreflective ovoid mass-like structures found on OCT images in the areas around the optic disc [8]
PHOMS was found in cases of optic disc drusen (ODD), optic disc edema (ODE), pseudo-optic disc edema, tilted disc syndrome (TDS), and optic neuritis, as well as other diseases [8, 12,13,14,15]

Summary

Introduction

Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are new imaging feature that have recently been revealed by EDI-OCT. In 2018, the term “PHOMS” was proposed by the Optic Disc Drusen Studies (ODDS) consortium to characterize the hyperreflective ovoid mass-like structures found on OCT images in the areas around the optic disc [8]. Understandings of PHOMS have improved because of the application of optical coherence tomography (OCT), enhanced depth imaging optical coherence tomography (EDI-OCT) and optical coherence tomography angiography (OCTA). We recommend adopting this refined definition [11]. The OCT finding was investigated in a larger, more definitive, series of patients and termed PHOMS, and we found that PHOMS existed in some optic nerve diseases This may indicate that PHOMS are novel and not well-characterized OCT findings occurring in several disorders of the optic nerve. We expect to provide more evidence for the clinical diagnosis and treatment of the disease

Methods

Results

Discussion

Conclusion