Abstract
Objective To investigate the risk factors underlying the occurrence and mortality of bloodstream infections (BSIs) with carbapenem-resistant Enterobacteriaceae (CRE). Methods Medical information was retrospectively analyzed from 148 cases of patients with Enterobacteriaceae BSIs at a medical center in China, between 2013 and 2015. Results The 30-day mortality rate in the CRE group was 65.4%. Indwelling urethral catheterization, admission to the ICU, use of antibiotics within 30 days, and BSIs from the respiratory system were associated with CRE BSIs. Lung infection, abdominal infection, central venous catheterization, and use of hormones within 30 days were associated with mortality. Conclusion The 30-day mortality rate of CRE BSIs was high. Lung infections, abdominal infections, central venous catheterization, and use of hormones within 30 days increased the mortality rate of Enterobacteriaceae BSIs.
Highlights
Infections with drug-resistant bacterial strains have increased which poses a challenge for anti-infection treatments in the clinical context and has become a serious problem in the eld of public health. e incidence of bloodstream infections is increasing and has become a major cause of the occurrence of infectious diseases and deaths worldwide [1]
Long-term bedbound patients accounted for 54.1% of the cases, and 62.2% of the patients had a medical institution admission history within 3 months. e bloodstream infections mainly originated from the urinary tract (28.4%) or respiratory system (25.0%) or were catheter related (22.3%)
Patients with carbapenem-resistant Enterobacteriaceae (CRE) infections accounted for 17.6% of the cases, and patients with XDR Enterobacteriaceae infections accounted for 4.0% of the cases
Summary
Infections with drug-resistant bacterial strains have increased which poses a challenge for anti-infection treatments in the clinical context and has become a serious problem in the eld of public health. e incidence of bloodstream infections is increasing and has become a major cause of the occurrence of infectious diseases and deaths worldwide [1]. Infections with drug-resistant bacterial strains have increased which poses a challenge for anti-infection treatments in the clinical context and has become a serious problem in the eld of public health. Bloodstream infections with multidrugresistant Enterobacteriaceae account for 71.5% of all bloodstream infections with multidrug-resistant bacterial strains [2]. Carbapenem-resistant Enterobacteriaceae (CRE) has been identi ed recently within all Enterobacteriaceae spp. e CHINET monitoring results show that Klebsiella pneumoniae accounts for the majority of cases of CRE infections among the Enterobacteriaceae spp., with drug resistance rates to imipenem and meropenem > 10% [3]. Is study was a retrospective analysis of medical information on bloodstream infections with Enterobacteriaceae (mainly Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, and Enterobacter aerogenes) with intent to identify the risk factors and prognosis for CRE bloodstream infections
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
