Clinical and Morphological Features of Sialadenoma Papilliferum: Report of Three Cases

Abstract

Sialadenoma papilliferum (SP), a rare and benign neoplasm of the salivary gland, accounts for approximately 1% of the minor salivary gland tumors. Here, we report 3 cases of SP, addressing their clinical and histopathological aspects. Each case presented as an exophytic and asymptomatic nodule in the palate. Under the hypothesis of squamous papilloma (case 1), fibrous hyperplasia (case 2), and sialadenitis (case 3), an excisional biopsy was performed. Microscopically, all the cases presented similar aspects, multiple exophytic papillary projections covered by stratified squamous epithelium that was contiguous with a proliferation of papillomatous ductal epithelium found below the surface. The basal cuboidal cell layer and a columnar cell luminal layer mostly lined the cystically dilated ducts and papillary projections. The supporting connective tissue contained a moderate mononuclear inflammatory infiltrate. Based on these findings, the 3 cases were diagnosed as SP, and there has been no evidence of recurrence after 5 years.