Abstract
Clinical and molecular features of Epstein-Barr virus-positive diffuse large B-cell lymphoma: Results in a multi-center trial.
Highlights
EBV-encoded RNA (EBER) in situ hybridization is the gold standard of EBV-infection status in tumors.[2]
141 patients available for serum samples, serum EBV DNA were positive in 14 cases, correlated with tumor EBER (P = 0.0036, concordance rate 82.3%, Table S2) and shared similar impact on ECOG≥2 (35.7% vs 11.81% P = 0.0298) and response to immunochemotherapy (CR, 64.3% vs 89.8%, P = 0.0186, Table S3)
EBV serological markers were not correlated with tumor EBER (Table S2) and prognosis (Figure 1A), viral capsid antigen (VCA) IgA-positive patients tend to have elevated serum LDH (67.4% vs 33.3%, P = 0.0264) and higher IPI (58.8% vs 22.2%, P = 0.0022, Table S3), providing additional clinical information in EBV-related DLBCL
Summary
EBV-encoded RNA (EBER) in situ hybridization is the gold standard of EBV-infection status in tumors.[2]. 141 patients available for serum samples, serum EBV DNA were positive in 14 cases, correlated with tumor EBER (P = 0.0036, concordance rate 82.3%, Table S2) and shared similar impact on ECOG≥2 (35.7% vs 11.81% P = 0.0298) and response to immunochemotherapy (CR, 64.3% vs 89.8%, P = 0.0186, Table S3). EBV serological markers were not correlated with tumor EBER (Table S2) and prognosis (Figure 1A), VCA IgA-positive patients tend to have elevated serum LDH (67.4% vs 33.3%, P = 0.0264) and higher IPI (58.8% vs 22.2%, P = 0.0022, Table S3), providing additional clinical information in EBV-related DLBCL.
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