Abstract
Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing or stable based on the activity of the disease. Further, the extent of involvement can be limited (localized disease) or extensive (generalized disease). The treatment of vitiligo therefore depends on the clinical classification/characteristics of the disease and usually comprises of 2 strategies. The first involves arresting the progression of active disease (to provide stability) in order to limit the area involved by depigmentation. The second strategy aims at repigmentation of the depigmented area. It is also important to maintain the disease in a stable phase and to prevent relapse. Accordingly, a holistic treatment approach for vitiligo should be individualistic and should take care of all these considerations. In this review, we shall discuss the vitiligo treatments and their important clinical and molecular aspects.
Highlights
Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae [1,2]
The first involves arresting the progression of active disease in order to limit the area involved by depigmentation
The aim is to prevent the ongoing destruction of melanocytes and to provide mediators that can stimulate the growth and proliferation of existing melanocytes, resulting in successful repigmentation
Summary
Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae [1,2]. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement [3]. It can be classified as progressing or stable based on the activity of the disease. The treatment of vitiligo depends on the clinical classification/characteristics of the disease and usually comprises of 2 strategies. The first involves arresting the progression of active disease (to provide stability) in order to limit the area involved by depigmentation. We shall discuss the vitiligo treatments and their important clinical and molecular aspects. The aim is to prevent the ongoing destruction of melanocytes and to provide mediators that can stimulate the growth and proliferation of existing melanocytes, resulting in successful repigmentation
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