Year-end Sale % OFF 
Abstract
<h2>Abstract</h2><h3>Background/Aims</h3> Combined hepatocellular-cholangiocarcinoma (HCC-CC) show dual hepatocellular and biliary epithelial differentiation. To better understand the relations between cholangiocarcinoma (CC), HCC-CC and hepatocellular carcinoma (HCC), we screened for genetic alterations. <h3>Methods</h3> A series of nine CC, 15 HCC-CC and three separated HCC and CC lesions (‘collision tumors') were screened for loss of heterozygosity (LOH) using 400 microsatellite markers and for p53 and β-catenin mutations. A comparison with a previously characterized series of 137 HCC was performed. <h3>Results</h3> In six cases of CC and HCC-CC, we identified <i>TP53</i> gene mutations. A CTNNB1/β-catenin was identified in two patients presenting collision tumors, but no mutations were found in CC or in HCC-CC. A high level of chromosome instability in both CC and HCC-CC was found. Recurrent specific LOH were identified at 3p and 14q in more than 50% of the CC and the HCC-CC cases, whereas these chromosomal regions were deleted in less than 10% of the HCC cases (<i>P</i><10<sup>−5</sup>). Minimal common regions of deletion (MCRD) were defined at 3p24-p14 and 14q24-q32, respectively. <h3>Conclusions</h3> These results suggest that combined HCC-CC are genetically closer to CC than HCC and common carcinogenesis pathways may be altered in HCC-CC and CC.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
