Abstract

Abstract Cytomegalovirus (CMV) infection is the most common cause of congenital infection in developed countries. It is thought that symptomatic congenital CMV (cCMV) infections are produced by a primary CMV infection in the majority of the cases, but recent case series published show a similar prevalence and severity of clinical findings and long-term sequels in nonprimary and primary cCMV infection. We report a case of nonprimary CMV infection in pregnancy with fetal neurological alterations. A positive quantitative polymerase chain reaction in amniotic fluid (AF) confirmed the diagnosis of cCMV infection that triggered a voluntary termination of pregnancy. Quantitative polymerase chain reaction assays of AF are used to confirm a fetal cCMV infection, and the invasive amniocentesis procedure is justified when abnormalities are found in ultrasound control, although they are not validated to use in AF.

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