Abstract
Background: Enteric fever is a major health problem in developing countries. Varied clinical presentation leads to diagnostic dilemmas resulting in fatal complications.Objective: To determine the socio-demographic, clinical manifestations, complications, antibiotic sensitivity pattern, treatment, and outcome in hospitalized enteric fever patients.Methods: A retrospective case record analysis of hospitalized patients in the age group one to 14 years with a discharge diagnosis of enteric fever was done in a tertiary care centre of Odisha over a period of three years (January 2017 to December 2019).Results: Of 112 patients, 75% of children belonged to the six to 14 years age group with a mean age of 7.6 +/- 3.6 years and a male to female ratio of 1.66:1. The peak of cases was seen during the month of January to June with 94% of cases occurring in low and middle socioeconomic status. The commonest presentation was fever in 98.21%; other features were vomiting (39.29%), pain in abdomen (21.43%), diarrhoea (26.79%), and anorexia (14.29%). Eosinopenia was found in 58.93%, transaminitis in 30.36%, and raised CRP in 73.21%. In 30 children blood culture was positive with sensitivity to third-generation cephalosporin. All isolates were nalidixic acid-resistant Salmonella Typhi (NARST). Complications were seen in 21.42%. All recovered and two left against medical advice.Conclusion: Enteric fever is a major threat in the paediatric age group. Early clinical diagnosis with rational use of antibiotics according to sensitivity pattern is important. Improved hygiene, vaccination, and awareness among people is necessary for prevention.
Highlights
IntroductionCausative organisms are Salmonella enterica serotype Typhi (S. typhi) or Salmonella enterica serotype Paratyphi A, B, or C
Enteric fever is a multi-systemic tropical infectious disease
Eosinopenia was found in 58.93%, transaminitis in 30.36%, and raised C-reactive protein (CRP) in 73.21%
Summary
Causative organisms are Salmonella enterica serotype Typhi (S. typhi) or Salmonella enterica serotype Paratyphi A, B, or C. It is prevalent in most underdeveloped countries, with India having a high disease burden of 214.2 per 100,000 individuals per year [1]. Clinical manifestations are non-specific, which may delay the diagnosis and treatment leading to fatal complications. Presenting complaints vary from mild constitutional symptoms to severe complications involving multiple organs. This study intended to determine the socio-demographic factors, clinical profile, complications, sensitivity pattern of antibiotics, the treatment used, and outcome in hospitalized children with enteric fever. Enteric fever is a major health problem in developing countries. Varied clinical presentation leads to diagnostic dilemmas resulting in fatal complications
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
