Clinical and laboratory features of metabolic syndrome in young indigenous and non-indigenous residents of Western Siberia (on the example of the Khanty-Mansiysk Autonomous Okrug – Yugra)

Abstract

Objective. To study the clinical and laboratory features of metabolic syndrome (MS) in young indigenous and non-indigenous residents of the Khanty-Mansi Autonomous Okrug – Yugra. Materials and methods. 863 young people aged 18–44 years were examined, of which 344 people had MS, 519 people without it. Comparison was made by ethnicity and gender. A general clinical examination, anthropometric study, measurement and assessment of blood pressure, lipid profile and fasting plasma glucose were conducted. Results. MS was detected in 42.9% of the total sample, in 40.7% of indigenous residents, and in 43.9% of non-indigenous residents. MS is common in 40.3% of men and 44.1% of women. MS was less common in indigenous men than in non-indigenous men (31.6% versus 43.5%). The incidence was identical in indigenous and non-indigenous women (44.1%). The prevalence of MS in indigenous men was 12.5% lower than in indigenous women (31.6% vs. 45.1%) (odds ratio 1.711; 95% confidence interval 0.980–2.986; p=0.058). The prevalence of MS in non-indigenous men (43.5%) and women (44.1%) was identical. Conclusion. A high prevalence of MS was established in young residents of the Khanty-Mansiysk Autonomous Okrug – Yugra. MS was more common in young women than in men. Indigenous women were 12.5% more likely to develop metabolic disorders than in indigenous men. The structure of MS in young people is characterized by frequent lipid profile disorders, in particular, hypertriglyceridemia. Abdominal obesity with dyslipidemia and hyperglycemia is common in non-native residents, and abdominal obesity with dyslipidemia and hypertension is common in the indigenous population.