Abstract
Introduction In 1960 Tamm 1 reported that inhibitors of DNA synthesis could suppress the multiplication of herpes simplex virus in tissue culture. The treatment of herpes keratitis with idoxuridine (5-iodo-2-desoxyuridine, IDU) however, was first suggested by Kaufman. 2 He and other authors have reported their generally good results in subsequent communications 3-16 in experimentally induced disease in rabbits as well as in the naturally occurring infection in man. Attempts to repeat this work yielded somewhat less encouraging results in our hands and, therefore, a more extensive investigation was initiated. Our studies reported in this paper include: (1) the effect of idoxuridine on herpes keratitis in rabbits and patients, correlated with the presence or absence of demonstrable virus; (2) the influence of the immune status of rabbits on the clinical and virological course of the disease; and (3) the influence of idoxuridine on virus and host cells in a tissue culture
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
