Abstract
Objective: to characterize the clinical and laboratory parameters of patients with HIV infection with newly diagnosed Kaposi’s sarcoma.Materials and methods. The analysis of clinical and laboratory data of 25 HIV-infected patients with newly diagnosed Kaposi’s sarcoma who were treated in the in-patient department of St. Petersburg Center for the Prevention and Control of AIDS and Infectious Diseases in 2009-2017Results. Ninety-two (n=23) patients were men. The median age at detecting HIV infection is 36 years. The manifestation age of Kaposi’s sarcoma is a median of 37 years. Elements of Kaposi’s sarcoma were located mainly on the skin of the lower and upper extremities, trunk, face and oral mucosa. Manifest CMV infection was registered in one patient, candidiasis of various localizations was found in 19 patients (76%), 2 of them also had one case of tuberculosis and toxoplasmosis. The viral load of HIV in the serum of patients upon admission to the hospital ranged from 26 159 to 2 755,549 copies/ml. The number of CD4 lymphocytes in the serum of patients is from 4 to 674 cells/μl. First-line antiretroviral drugs were prescribed to 20 (80%) patients, while the positive dynamics of sarcoma was observed in 8 patients. Four (16%) patients received antitumor treatment. The duration of hospitalization of patients ranged from 8 to 85 days (median 29). Twenty-one patients were discharged from the hospital, death was registered in 4 patients (16%).Conclusion. Characteristics of patients with HIV infection with newly diagnosed Kaposi’s sarcoma are: the predominance of males aged 30-39 years; skin lesions of the limbs and trunk in the debut of the clinical picture of sarcoma; laboratory signs of pronounced immunodeficiency (in 75% of patients, CD4 lymphocytes in the serum are less than 200 cells/μl); high viral load of HIV in serum (in 88% of patients more than 100 000 copies/ml); frequent combination with other opportunistic diseases.
Highlights
Objective: to characterize the clinical and laboratory parameters of patients with HIV infection with newly diagnosed Kaposi’s sarcoma
Риск развития злокачественных новообразований у больных ВИЧ-инфекцией выше, чем в общей популяции
Осложнения саркомы Капоши зарегистрированы у 4 пациентов (16%): отеки нижних конечнос тей (4 чел.) и желудочно-кишечное кровотечение (1 чел.)
Summary
Клинико-лабораторная характеристика больных ВИЧ-инфекцией с впервые выявленной саркомой Капоши. Антонова 1 1Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Санкт-Петербург, Россия 2 Научно-исследовательский институт гриппа им. Резюме Цель: охарактеризовать клинические и лабораторные показатели больных ВИЧ-инфекцией с впервые выявленной саркомой Капоши. Проведен анализ клинико-лабораторных данных 25 больных ВИЧ-инфекцией с впервые выявленной саркомой Капоши, проходивших лечение в стационаре Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями в 2009–2017 гг. Возраст манифестации саркомы Капоши – медиана 37 лет. Вирусная нагрузка ВИЧ в сыворотке крови больных при поступлении в стационар составила от 26 159 до 2 755 549 коп/мл. Характеристиками больных ВИЧинфекцией с впервые выявленной саркомой Капоши являются: преобладание лиц мужского пола в возрасте 30–39 лет; поражение кожи конечностей и туловища в дебюте клинической картины саркомы; лабораторные признаки выраженного иммунодефицита
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